Search results for "Hydrophobic basic drugs"

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Comparison between micellar liquid chromatography and capillary zone electrophoresis for the determination of hydrophobic basic drugs in pharmaceutic…

2007

[EN] The determination of highly hydrophobic basic compounds by means of conventional reversed-phase liquid chromatographic methods has several drawbacks. Owing to the characteristics of micellar liquid chromatography (MLC) and capillary electrophoresis (CE), these techniques could be advantageous alternatives to reversed-phase chromatographic methods for the determination of these kinds of compounds. The objective of this study was to develop and compare MLC and CE methods for the determination of antipsychotic basic drugs (amitryptiline, haloperidol, perphenazine and thioridazine) in pharmaceutical preparations. The chromatographic determination of the analytes was performed on a Kromasil…

AnalyteResolution (mass spectrometry)Capillary actionClinical BiochemistrySensitivity and SpecificityBiochemistryAnalytical ChemistryCapillary electrophoresischemistry.chemical_compoundCapillary electrophoresisBromideDrug DiscoveryQUIMICA ANALITICAAntipsychotic drugsMolecular BiologyPharmacologyDetection limitChromatographyElectrophoresis CapillaryReproducibility of ResultsGeneral MedicineHydrogen-Ion ConcentrationReference StandardsElectrophoresisPharmaceutical PreparationschemistryHydrophobic basic drugsMicellar liquid chromatographyCalibrationPharmaceutical analysisHydrophobic and Hydrophilic InteractionsCetyltrimethylammonium bromideMicellar liquid chromatographyAntipsychotic AgentsChromatography Liquid

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